Guarulhos is the second biggest municipality in São Paulo metropolitan area. Guarulhos is characterized by deep social inequalities and environmental injustices, which can be observed in its sanitation infrastructure that poses serious pollution risks for the city’s water supply. The challenges are not restricted to water and sanitation, but also apply to the provision of energy and nutritious food, particularly in the informal settlements. Furthermore, Guarulhos shares its municipal borders and some of its service provision with other municipalities in the São Paulo metropolitan region, which makes it a compelling case for analysing the spatial trans-boundarly challenges of the urban Nexus.